Neurodegenerative diseases are group of disorders, that are characterized by the progressive and gradual degeneration of structure and function of nervous system. Alzheimer Disease (AD) is the leading neurodegenerative disorder in the world today accounting for approximately two-third cases of dementia. AD is associated with the memory deficits and the progressive impairment in the cognitive function and behavior. The pathological feature of Aβ includes the β-amyloid plaques, hyperphosphorylated neurofibrillary tangles and neurotransmitter deficits. Direct imaging of amyloid plaques by synthesizing different molecular probes in AD patients would be very useful for the early diagnosis of Alzheimer disease by detecting the presence and accumulation of Aβ peptides. In the present work, an effort has been dedicated in synthesizing a library of tethered biaryl compounds with variable linker length. These scaffolds are expected to display good affinity towards Aβ plaques by interacting through π-stacking. All the compounds in the library were characterized via NMR, IR, and GC-MS and are ready for subsequent biological analysis.