Sulfonamides are vital components in many pharmaceuticals and agrochemicals, yet traditional synthesis methods face challenges due to instability and harsh reaction conditions. In response, Dr. Ghayoor Abbas Chotana from Department of Chemistry and Chemical Engineering SBASSE along with his team members Ismat Nawaz, Maryam Nawaz, and Dr. Rahman Shah Zaib Saleem, have developed an innovative catalytic approach for Sulfur (VI) Fluoride Exchange (SuFEx) reactions, published in Advanced Synthesis & Catalysis.
Using affordable organic bases and leveraging the unexpected role of glass reaction vessels, the team’s method simplifies sulfonamide synthesis while adhering to green chemistry principles. This breakthrough enables safer, more efficient production of sulfonamides for drug discovery and highlights how everyday materials like glass can influence chemical reactions.
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The work reflects LUMS’ commitment to advancing science and sustainability, contributing to global innovation in chemistry.