Synthesis of Organoselenium Compounds as Potential Candidates against Alzheimer’s Disease
Amide bond is regarded as key functional group to many natural products, polymers and serve as a backbone in peptides synthesis. Since the advancement in drugs synthesis, a number of methods are available for its formation but these are considered as most expensive and sophisticated because of unfavorable kinetic and thermodynamics of the process, requirement of stoichiometric amounts of promoters or metal mediators, long reaction routes and harsh reaction conditions. In order to circumvent these associated challenges, their direct one-step synthesis from esters/acids and amines had been, and continues to be the focus of significant attention in synthetic chemistry and could be the most crucial revolution in pharmaceutical industry as it is evident in recent surveys where 25% of the registered drugs possess amide functionality. Following the same direction, direct one-step amide bond formation strategies from esters/acids and amines by using green chemistry protocols will be investigated.
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