Event date:
Nov 15 2021 7:00 pm

CCEW-7: Redox Regulation via Cellular Thiolstat- A Symphony in Pink

Professor Claus Jacob
Reactive Sulfur species (RSS) have been receiving increasing attention due to their redox active nature especially from the perspective of biological chemistry. The remarkable developments in this field have stemmed from simple cysteine side chains in proteins and enzymes serving as centres of redox signalling and control and paved the way for innovative concepts, such as the sulfur redoxome, the sulfenome and the cellular thiolstat. The redox sensitive cysteine residues have therefore been identified as preferred targets of RSS, certain metal ions, and the emerging class of Reactive Selenium Species (RSeS). Moreover, the cellular redoxome facilitates the redox modulation and potent activity of the highly selective catalytic sensor/effector agents against a broad spectrum of redox related diseases. This field, together with nanotechnology will eventually expand and broaden the horizons toward green phyto-protectants. Indeed, the impact of redox active food ingredients and multifunctional redox modulators on cells is intricate. Contemporary techniques such as redox proteomics and chemogenetic phenotype profiling in combination with fluorescent-based "intracellular diagnostics" can be utilized to elucidate certain changes, pathways and eventually also mode(s) of action. Indeed, chalcogen based redox systems will certainly define future research and development in nutrition, drug design, cosmetics, green agriculture and waste management.

Professor Claus Jacob will be speaking about "Redox regulation via cellular thiolstat – A symphony in Pink" in the 7th session of CCEW on November 15, 2021 at 7pm PKT (GMT+5).

Professor Claus Jacob is currently associated with the Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Saarbruecken, Germany.

To join us for the session, kindly REGISTER via this link: https://forms.gle/HE7xtJpxK64TF9Uv9

About the speaker:

Prof. Jacob obtained his BSc in chemistry from the University of Leicester in 1993 and his DPhil from Oxford in 1997. From 1996 to 1999, he spent time as a Postdoc at Harvard Medical School. In 1999, he took up the lecturer position in inorganic chemistry at the University of Exeter, moved to Saarbrücken in 2005 as a junior professor, and established a research group on bioorganic chemistry in the School of Pharmacy. In June 2011, Prof. Jacob got his full professor at Saarland University.

Prof. Jacob has edited a book on 'Redox Signaling and Regulation in Biology and Medicine published by the Wiley-VCH. He was awarded a 3rd Interregional Research Prize (jointly with Prof. Kirsch and Dr. Diederich) and an award from the Foundation for the Advancement of the German-Luxemburgish cooperation in Science (jointly with Dr. Diederich).

Prof. Jacob is a fellow of Higher Education Academy and Royal Society of Chemistry (UK). He was awarded an EPSRC Advanced Research Fellow with the University of Exeter. He is the CEO of Dr. Burkholz Life Science Consulting UG (haftungsbeschränkt) and Chairman of Exeter Antioxidant Therapeutics Ltd.