Advancements in data capture and imaging technologies have transformed the acquisition of high-resolution 3D data, enabling scientists to study object characteristics across diverse domains. Visualization systems have become essential tools in scientific and biomedical workflows, aiding in the exploration and analysis of such data. While most visualization systems are designed for desktop setups, recent developments in eXtended Reality (XR) technologies -- virtual reality (VR), augmented reality (AR), and mixed reality (MR) -- present novel avenues for human information-processing capability. In this talk, we will explore designing end-to-end visualization systems for a spectrum of XR and visual display modalities, with a specific focus on applications in neuroscience and atmospheric sciences. We will also describe the design and construction of some of the world’s most unique immersive display facilities, namely, the Reality Deck, the world's largest (1.5Gpixel) immersive display; the Silo, the world’s highest resolution stereoscope display; and FlexiCAVE, the world’s first dynamically configurable display facility.