Event date:
Mar 3 2021 9:00 am

Genome-Wide Mapping of Protein-DNA Interaction Dynamics

Speaker(s)
Prof. Dr. Steve Henikof
Venue
Zoom/Online
Abstract
We recently introduced new tools for high-resolution genome-wide chromatin profiling and have applied them to study chromatin organization and dynamics in a variety of model systems, including yeast, flies and mammals. Among the questions addressed are: How do transcription factors find their binding sites in DNA packaged into nucleosomes? How are nucleosomes depleted from gene regulatory regions? What is the relationship between nucleosome deposition pathways and chromatin deregulation in disease? Our findings illustrate ways in which chromatin dynamics can play a central role in regulating gene expression and silencing.


Prof. Dr. Steve Henikof joins us LIVE to talk about “Genome-wide mapping of protein-DNA interaction dynamics” in Zooming Molecular & Cellular Biology Series. 

He is a faculty member of the Fred Hutchinson Cancer Research Center and is an investigator of the Howard Hughes Medical Institute, an affiliate professor of Genome Sciences at the University of Washington. Steve is an authority and a highly accomplished scientist whose lifelong work revolves around understanding chromosome structure and dynamics and how they influence gene regulation. He has also contributed significantly to our understanding of centromeric chromatin structure and his lab has developed tools which we all use in our labs to investigate binding of proteins with DNA.

 

About the speaker:

Dr. Steve Henikoff studies chromosomes, chromatin dynamics and epigenetics and develops genomics and computational tools to facilitate this research. He received a BS from the University of Chicago and a PhD from Harvard University and did post-doctoral work at the University of Washington. He has been a faculty member of the Fred Hutchinson Cancer Research Center since 1981. He is also an investigator of the Howard Hughes Medical Institute, an affiliate professor of Genome Sciences at the University of Washington, a member of the National Academy of Sciences and co-Editor-in-Chief of the open access journal Epigenetics & Chromatin.