Dr Muhammad Saeed Joined LUMS in 2014 as an Associate Professor. He established the Bioorganic and Medicinal Chemistry (BMC) group in The Department of Chemistry and Chemical Engineering. Originally trained as synthetic organic chemist, he has extensive postdoctoral research experience at the interface of chemistry and biology. He is interested to address the modern challenges in biological sciences and medicinal chemistry by using the tools of organic chemistry. More specifically, he pursues rational antiviral and anticancer drug designing and discovery by using modern day techniques of computational modeling, protein dynamics and simulations, supported by the conventional wet-chemistry of organic synthesis and high-throughput screening of synthetic compounds and natural products.

Dr Saeed received his PhD degree in organic chemistry from Eberhard-Karls University of Tuebingen, Germany under the supervision of Prof. Dr. Dr (hc mult) Wolfgang Voelter, after accomplishing total syntheses of several natural products and medicinal analogs using the chirality and topology of abundant carbohydrates. After PhD, he joined the research group of Prof. Ercole Cavalieri, DSc at the Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, USA, where he participated as chemical biologist in mechanistic investigation of cancer initiation by estrogens and related carcinogenic compounds. Before joining LUMS, he has also spent some time in the Department of Chemistry, University of Iowa, where he worked as a visiting assistant professor as well as conducted research as postdoctoral scholar with Prof. Amnon Kohen, DSc in the area of development of radiopharmaceuticals as positron emission tomography (PET) tracers. He has published around 50 research articles in reputed international journals, such as J. Biol. Chem., Int. J. Cancer, Free Rad. Biol. Med. Chem. Res. Toxicol., and Tetrahedron Lett. His is currently investigating proteases of different viruses (COVID-19, dengue, HCV) as drug targets for designing efficient direct-acting antivirals (DAAs).

Click here to view Dr. Saeed’s research group webpage
 

Title Publication Author Year
Erratum: Catechol-O-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells (PLoS ONE (2013) 8:1 DOI: 10.1371/annotation/8c8c0cae-7f2f-4f37-9807- 2d02b6c14db1) PLoS ONE Salama S.A., Kamel M.W., Botting S., Salih S.M., Borahay M.A., Hamed A.A., Kilic G.S., Saeed M., Williams M.Y., Diaz-Arrastia C.R., 2013
Effect of Tumour Necrosis Factor-Alpha on Estrogen Metabolic Pathways in Breast Cancer Cells Journal of Cancer Kamel M., Shouman S., El-Merzebany M., Kilic G., Veenstra T., Saeed M., Wagih M., Diaz-Arrastia C., Patel D., Salama S., 2012
Mechanism of DNA depurination by carcinogens in relation to cancer initiation IUBMB Life Cavalieri E., Saeed M., Zahid M., Cassada D., Snow D., Miljkovic M., Rogan E., 2012
Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson's disease IUBMB Life Zahid M., Saeed M., Yang L., Beseler C., Rogan E., Cavalieri E.L., 2011
Formation of diethylstilbestrol-DNA adducts in human breast epithelial cells and inhibition by resveratrol Journal of Steroid Biochemistry and Molecular Biology Hinrichs B., Zahid M., Saeed M., Ali M.F., Cavalieri E.L., Rogan E.G., 2011
The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk Journal of Steroid Biochemistry and Molecular Biology Williams-Brown M.Y., Salih S.M., Xu X., Veenstra T.D., Saeed M., Theiler S.K., Diaz-Arrastia C.R., Salama S.A., 2011
Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells Free Radical Biology and Medicine Zahid M., Saeed M., Beseler C., Rogan E.G., Cavalieri E.L., 2011
N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells Free Radical Biology and Medicine Zahid M., Saeed M., Ali M.F., Rogan E.G., Cavalieri E.L., 2010
Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease Free Radical Biology and Medicine Zahid M., Saeed M., Rogan E.G., Cavalieri E.L., 2010
Catechol-O-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells PLoS ONE Salama S.A., Kamel M.W., Botting S., Salih S.M., Borahay M.A., Hamed A.A., Kilic G.S., Saeed M., Williams M.Y., Diaz-Arrastia C.R., 2009
NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells Journal of Steroid Biochemistry and Molecular Biology Singh S., Zahid M., Saeed M., Gaikwad N.W., Meza J.L., Cavalieri E.L., Rogan E.G., Chakravarti D., 2009
Depurinating naphthalene-DNA adducts in mouse skin related to cancer initiation Free Radical Biology and Medicine Saeed M., Higginbotham S., Gaikwad N., Chakravarti D., Rogan E., Cavalieri E., 2009
Mechanism of metabolic activation and DNA adduct formation by the human carcinogen diethylstilbestrol: The defining link to natural estrogens International Journal of Cancer Saeed M., Rogan E., Cavalieri E., 2009
Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol Free Radical Biology and Medicine Zahid M., Gaikwad N.W., Ali M.F., Lu F., Saeed M., Yang L., Rogan E.G., Cavalieri E.L., 2008
Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells Cancer Prevention Research Lu F., Zahid M., Wang C., Saeed M., Cavalieri E.L., Rogan E.G., 2008
Inhibition of catechol-O-methyltransferase increases estrogen-DNA adduct formation Free Radical Biology and Medicine Zahid M., Saeed M., Lu F., Gaikwad N., Rogan E., Cavalieri E., 2007
Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibition Journal of Steroid Biochemistry and Molecular Biology Lu F., Zahid M., Saeed M., Cavalieri E.L., Rogan E.G., 2007
Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol International Journal of Cancer Saeed M., Rogan E., Fernandez S.V., Sheriff F., Russo J., Cavalieri E., 2007
Formation of depurinating N3adenine and N7guanine adducts after reaction of 1,2-naphthoquinone or enzyme-activated 1,2-dihydroxynaphthalene with DNA. Implications for the mechanism of tumor initiation by naphthalene Chemico-Biological Interactions Saeed M., Higginbotham S., Rogan E., Cavalieri E., 2007
The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: Implications for tumor-initiating activity Chemical Research in Toxicology Zahid M., Kohli E., Saeed M., Rogan E., Cavalieri E., 2006
Development of monoclonal antibodies to 4-hydroxyestrogen-2-N- acetylcysteine conjugates: Immunoaffinity and spectroscopic studies Chemical Research in Toxicology Markushin Y., Kapke P., Saeed M., Zhang H., Dawoud A., Rogan E.G., Cavalieri E.L., Jankowiak R., 2005
Novel spiro-quinone formation from 3???-hydroxydiethylstilbestrol after oxidation with silver oxide Tetrahedron Letters Saeed M., Rogan E., Cavalieri E., 2005
Synthesis of the catechols of natural and synthetic estrogens by using 2-iodoxybenzoic acid (IBX) as the oxidizing agent Steroids Saeed M., Zahid M., Rogan E., Cavalieri E., 2005
Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3,4-quinone and hexestrol-3???,4???-quinone.: Implications for mutagenic activity Steroids Saeed M., Zahid M., Gunselman S.J., Rogan E., Cavalieri E., 2005
Formation of the depurinating N3adenine and N7guanine adducts by reaction of DNA with hexestrol-3???,4???-quinone or enzyme-activated 3???-hydroxyhexestrol: Implications for a unifying mechanism of tumor initiation by natural and synthetic estrogens Steroids Saeed M., Gunselman S.J., Higginbotham S., Rogan E., Cavalieri E., 2005