Dr. Amir Faisal received his PhD in Cell Biology from Friedrich Miescher Institute for Biomedical Research/University of Basel, Switzerland in 2004. During his PhD he identified novel roles for Shc protein, an important adaptor downstream of tyrosine kinases, in insulin signalling and cytoskeletal reorganization. He received his first postdoctoral training (2004-2008) in Protein Phosphorylation Laboratory at London Research Institute where he discovered that another adaptor protein, MyD88, couples Protein Kinase C epsilon to Toll like receptors during innate immunity. From 2008 to 2014, he worked at Cancer Therapeutics Unit of Institute of Cancer Research in Sutton first as postdoctoral fellow and later as senior scientist. He played an important role in progression of several drug discovery projects, one of which resulted in discovery of a pre-clinical development candidate that will undergo phase I clinical trials in 2016. After joining LUMS in August 2014, he has been establishing a cancer therapeutics lab at SBASSE.

Title Publication Author Year
A Personalized Therapeutics Approach Using an In Silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer Frontiers in Oncology 2021
Synthesis of diosgenin conjugated gold nanoparticles using algal extract of Dictyosphaerium sp. and in-vitro application of their antiproliferative activities Materials Today Communications 2021
CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells British Journal of Cancer 2021
Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors Journal of Natural Products 2020
Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil International Journal of Pharmaceutics 2020
Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation Stem Cell Research and Therapy 2020
A cell-based high-throughput screen identifies inhibitors that overcome P-glycoprotein (Pgp)mediated multidrug resistance PLoS ONE 2020
Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736 Blood Advances 2020
A facile and versatile route to functional poly(propylene) surfaces via UV-curable coatings Reactive and Functional Polymers 2019
Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species European Journal of Pharmaceutical Sciences 2019
Effect of Extraction Methodologies on Antioxidant Potential and Synergistic Anticancer Behavior of Leaf Extract of Polygonum amplexicaule Against HCT-116 Cells Iranian Journal of Science and Technology, Transaction A: Science 2019
Synthesis and evaluation of novel ??-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance Bioorganic Chemistry 2019
Hydrothermal synthesis of carbon nanodots from bovine gelatin and PHM3 microalgae strain for anticancer and bioimaging applications Nanoscale Advances 2019
Identification and evaluation of novel drug combinations of Aurora kinase inhibitor CCT137690 for enhanced efficacy in oral cancer cells Cell Cycle 2019
High proliferation rate and a compromised spindle assembly checkpoint confers sensitivity to the MPS1 inhibitor BOS172722 in triple-negative breast cancers Molecular Cancer Therapeutics 2019
Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance Scientific Reports 2018
ATLANTIS - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and Reprogramming Scientific Reports 2018
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722) Journal of Medicinal Chemistry 2018
CDK1 inhibition facilitates formation of syncytiotrophoblasts and expression of human Chorionic Gonadotropin Placenta 2018
Erratum: Author Correction: Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance (Scientific reports (2018) 8 1 (3305)) Scientific reports 2018
Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis Oncotarget 2018
Nicotine exposure augments renal toxicity of 5-azacytidine through p66shc: Prevention by resveratrol Anticancer Research 2017
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy British Journal of Cancer 2017
Synthesis and evaluation of modified chalcone based p53 stabilizing agents Bioorganic and Medicinal Chemistry Letters 2017
Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell lines Natural Product Research 2017