Faculty Profile

Dr. Rahman Shah Zaib Saleem

Associate Professor

Department Of Chemistry & Chemical Engineering

Dr. Saleem joined LUMS in 2012 as an assistant professor and was tenured and promoted to associate professor in 2020.  He is an enthusiastic experienced organic chemist with a proven track record in the medicinal chemistry and materials. He enjoys teaching and training organic chemistry, spectroscopy, medicinal chemistry and drug discovery courses at undergraduate and postgraduate level. He builds effective collaborations within and outside of the institution.
In the medicinal chemistry, he has expertise in the discovery of lead molecules for various cellular targets. His specialties include hit and lead generation, lead optimization, medicinal chemistry, organic synthesis and methodology, structure-based drug design, data analysis, natural product isolation and structure elucidation.
On the materials front, he is also working on the novel metal-free organic dyes for solar cell and organic scaffolds for metal-organic frameworks (MOFs) and modification of the drug molecules to prepare nanoparticles for subsequent evaluation. As an organic chemist, he has also done the isolation, characterization & total synthesis of the natural products.

Post-doctoral/Work experience
Jan 2020- to date     Associate Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Jan 2012- Jan 2020     Assistant Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Summer 2019    DAAD fellow, University of Saarland, Germany
Summer 2016    DAAD fellow, University of Saarland, Germany
Summer 2014    Herchel Smith Post-Doctoral Fellow, University of Cambridge, UK
Summer 2012    Post-Doctoral Research Visit, University of Bristol, UK
Education
2011      PhD, Michigan State University (Advisor: Prof. Jetze J. Tepe, Fulbright Fellowship)
2004      MPhil, GC University, Lahore, Pakistan
2002      MSc, GC University, Lahore, Pakistan (First position in the university)
2000      BSc, Punjab University, Lahore (Government College, Gujranwala), Pakistan
Roll of Honors
Academic roll of honor (2002)
Awards
2019                     DAAD Research Stays for University Academics and Scientists, University of Saarland
2016                     DAAD Research Stays for University Academics and Scientists, University of Saarland
2013-14                Herchel Smith fellowship, University of Cambridge
2012                     LUMS’ SSE Deans travel award for the summer research visit to University of Bristol
2006-11                Fulbright PhD fellowship
2011                     Dissertation completion fellowship
2011                     Graduation school travel fellowship, Michigan State University
2006                     Walter R. and Margaret W. Yates Memorial fellowship, Michigan State University
2006                     XIVth star award 2005: 125 distinguished men & women: Leaders of the new millennium
2003                     Orient Dr. Ata-ur-Rehman chemistry award and gold medal
2002                     Academic excellence award, GC University Lahore
2002                     Prof. Abdul Rashid Tariq gold medal
1998                     President talent farming award
1996                     Jamiat gold medal

Research group page: OrgChem.lums.edu.pk

Title Publication Author Year
Effect of Extraction Methodologies on Antioxidant Potential and Synergistic Anticancer Behavior of Leaf Extract of Polygonum amplexicaule Against HCT-116 Cells Iranian Journal of Science and Technology, Transaction A: Science Batool S., Ullah S., Tabassum S., Bilal A., Faisal A., Saleem R.S.Z., Ahmad M.S. 2019
Synthesis and evaluation of novel ??-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance Bioorganic Chemistry Riaz S., Iqbal M., Ullah R., Zahra R., Chotana G.A., Faisal A., Saleem R.S.Z. 2019
Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation Bioorganic Chemistry Farrukh S.U.B., Javed I., Ather A.Q., Emwas A.-H., Alazmi M., Gao X., Chotana G.A., Davis T.P., Ke P.C., Saleem R.S.Z. 2019
A Novel One-Pot Three-Component Reaction for Rapid Access of Arylidene 2-Aminoimidazolone Derivatives ChemistrySelect Hanif A., Sardar A., Alazmi M., Tariq H., Emwas A.-H., Gao X., Chotana G.A., Zaib Saleem R.S. 2019
Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance Scientific Reports Manzoor S., Bilal A., Khan S., Ullah R., Iftikhar S., Emwas A.-H., Alazmi M., Gao X., Jawaid A., Saleem R.S.Z., Faisal A. 2018
Synthesis, in vitro and in silico studies of S-alkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as cholinesterase inhibitors Pakistan journal of pharmaceutical sciences Arfan M., Siddiqui S.Z., Abbasi M.A., Rehman A., Shah S.A.A., Ashraf M., Rehman J., Saleem R.S.Z., Khalid H., Hussain R., Khan U. 2018
Iridium-Catalyzed Regioselective Borylation of Substituted Biaryls Synthesis (Germany) Asghar S., Shahzadi T., Alazmi M., Gao X., Emwas A.-H., Saleem R.S.Z., Batool F., Chotana G.A. 2018
Erratum: Author Correction: Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance (Scientific reports (2018) 8 1 (3305)) Scientific reports Manzoor S., Bilal A., Khan S., Ullah R., Iftikhar S., Emwas A.-H., Alazmi M., Gao X., Jawaid A., Saleem R.S.Z., Faisal A. 2018
Facile Synthesis of Halogen Decorated para -/ meta -Hydroxybenzoates by Iridium-Catalyzed Borylation and Oxidation Synthesis (Germany) Shahzadi T., Saleem R.S.Z., Chotana G.A. 2018
The selenium-nitrogen bond as basis for reactive selenium species with pronounced antimicrobial activity Current Organic Synthesis Rendekova J., Vlasakova D., Arsenyan P., Vasiljeva J., Nasim M.J., Witek K., Dominguez-Alvarez E., Zeslawska E., Manikova D., Tejchman W., Saleem R.S.Z., Rory K., Handzlik J., Chovanec M. 2017
Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. Aurantiaca strains isolated from cactus, cotton, and para grass Journal of Microbiology and Biotechnology Shahid I., Rizwan M., Baig D.N., Saleem R.S., Malik K.A., Mehnaz S. 2017
Synthesis and evaluation of modified chalcone based p53 stabilizing agents Bioorganic and Medicinal Chemistry Letters Iftikhar S., Khan S., Bilal A., Manzoor S., Abdullah M., Emwas A.-H., Sioud S., Gao X., Chotana G.A., Faisal A., Saleem R.S.Z. 2017
Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel Journal of Materials Chemistry B Sohail M.F., Javed I., Hussain S.Z., Sarwar S., Akhtar S., Nadhman A., Batool S., Irfan Bukhari N., Saleem R.S.Z., Hussain I., Shahnaz G. 2016
A concise total synthesis of hymenialdisine Tetrahedron Letters Saleem R.S.Z., J. Tepe J. 2015
Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain pseudomonas aurantiaca PB-St2 Journal of Natural Products Mehnaz S., Saleem R.S.Z., Yameen B., Pianet I., Schnakenburg G., Pietraszkiewicz H., Valeriote F., Josten M., Sahl H.-G., Franzblau S.G., Harald G. 2013
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors Bioorganic and Medicinal Chemistry Saleem R.S.Z., Lansdell T.A., Tepe J.J. 2012
Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors ACS Chemical Biology Nguyen T.N.T., Saleem R.S.Z., Luderer M.J., Hovde S., Henry R.W., Tepe J.J. 2012
Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolones Journal of Organic Chemistry Saleem R.S.Z., Tepe J.J. 2010
5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid Acta Crystallographica Section E: Structure Reports Online Zia-Ur-Rehman M., Elsegood M.R.J., Akbar N., Shah Zaib Saleem R. 2008