Dr. Saleem is employing organic synthesis to prepare compounds for application in the areas of medicinal chemistry and materials. In the medicinal chemistry, his current focus is in the area of cancer research (targeting p53-MDM2 interaction, centrosome clustering and tubulin polymerization inhibition), diabetes research, preparation of novel metal-free organic dyes for solar cell and organic scaffolds for metal organic frameworks (MOFs). Other interests include national product isolation and identification and analysis of food for toxicology studies.
Dr. Saleem completed his doctoral studies in synthetic organic/medicinal chemistry from the Michigan State University as Fulbright Scholar in 2011. His doctoral work corresponded to the development of novel dipolar cycloaddition methodology, synthesis of natural product (Hymenialdisine) and preparation of inhibitors of check-point kinase 2 and NF-KappaB. His postdoctoral visit to University of Bristol involve synthesis of novel AAA+ ATPase modulators. His postdoctoral stay at the University of Cambridge involved synthesis of the protein-protein-interaction modulators and his recent visit to University of Saarland as DAAD fellow involved synthesis of selenium containing redox modulators. Earlier, Dr. Rahman Saleem obtained his M.Sc. in Chemistry from GC University, Lahore, Pakistan with distinction (Gold Medal and Academic Role of Honor) in 2002 and MPhil in Chemistry in 2004. He served in GC University, Lahore for an academic year and then in Gujranwala Institute of Future Technologies as lecturer for three years. During this time he was awarded Orient Dr. Ata-ur-Rehman Chemistry Award & XIVth Star Award and was selected to present Pakistan in the 56th Meeting with Nobel Laureates in Lindau, Germany. Dr. Saleem, during his time in LUMS, has completed three research projects and has presented hiss research work in various international and national conferences including the US National Organic Symposium.
|Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance||Scientific Reports||Manzoor S., Bilal A., Khan S., Ullah R., Iftikhar S., Emwas A.-H., Alazmi M., Gao X., Jawaid A., Saleem R.S.Z., Faisal A.||2018|
|Iridium-Catalyzed Regioselective Borylation of Substituted Biaryls||Synthesis (Germany)||Asghar S., Shahzadi T., Alazmi M., Gao X., Emwas A.-H., Saleem R.S.Z., Batool F., Chotana G.A.||2018|
|Facile Synthesis of Halogen Decorated para -/ meta -Hydroxybenzoates by Iridium-Catalyzed Borylation and Oxidation||Synthesis (Germany)||Shahzadi T., Saleem R.S.Z., Chotana G.A.||2018|
|The selenium-nitrogen bond as basis for reactive selenium species with pronounced antimicrobial activity||Current Organic Synthesis||Rendekova J., Vlasakova D., Arsenyan P., Vasiljeva J., Nasim M.J., Witek K., Dominguez-Alvarez E., Zeslawska E., Manikova D., Tejchman W., Saleem R.S.Z., Rory K., Handzlik J., Chovanec M.||2017|
|Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. Aurantiaca strains isolated from cactus, cotton, and para grass||Journal of Microbiology and Biotechnology||Shahid I., Rizwan M., Baig D.N., Saleem R.S., Malik K.A., Mehnaz S.||2017|
|Synthesis and evaluation of modified chalcone based p53 stabilizing agents||Bioorganic and Medicinal Chemistry Letters||Iftikhar S., Khan S., Bilal A., Manzoor S., Abdullah M., Emwas A.-H., Sioud S., Gao X., Chotana G.A., Faisal A., Saleem R.S.Z.||2017|
|Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel||Journal of Materials Chemistry B||Sohail M.F., Javed I., Hussain S.Z., Sarwar S., Akhtar S., Nadhman A., Batool S., Irfan Bukhari N., Saleem R.S.Z., Hussain I., Shahnaz G.||2016|
|A concise total synthesis of hymenialdisine||Tetrahedron Letters||Saleem R.S.Z., J. Tepe J.||2015|
|Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain pseudomonas aurantiaca PB-St2||Journal of Natural Products||Mehnaz S., Saleem R.S.Z., Yameen B., Pianet I., Schnakenburg G., Pietraszkiewicz H., Valeriote F., Josten M., Sahl H.-G., Franzblau S.G., Harald G.||2013|
|Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors||Bioorganic and Medicinal Chemistry||Saleem R.S.Z., Lansdell T.A., Tepe J.J.||2012|
|Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors||ACS Chemical Biology||Nguyen T.N.T., Saleem R.S.Z., Luderer M.J., Hovde S., Henry R.W., Tepe J.J.||2012|
|Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolones||Journal of Organic Chemistry||Saleem R.S.Z., Tepe J.J.||2010|
|5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid||Acta Crystallographica Section E: Structure Reports Online||Zia-Ur-Rehman M., Elsegood M.R.J., Akbar N., Shah Zaib Saleem R.||2008|