The Syed Babar Ali School of Science and Engineering (SBASSE) presents two sessions
"Restoration of TGF-β Signalling Using Small RNAs: A Therapeutic Strategy for Cancer" and "Alternative Splicing Factor RBFOX2 Induces microRNA Strand Bias"
Dr. Muhammad Afzal Dogar
Date: Wednesday, October 11, 2017
Time: 3:30 pm – 4:30 pm
Venue: Smart Room, 4th Floor SBASSE, LUMS
Dr. Muhammad Tariq
Cancer cells secreting excess latent TGF-β are often resistant to TGF-β induced growth inhibition. We discovered a mechanism of escape from TGF-β-mediated growth inhibition at the earliest point in the signalling pathway is regulated by microRNAs.
MicroRNAs derive from stem-loop structures which are processed by the Dicer to mature miRNAs. Here we show that in some cell-types the alternative splicing factor RBFOX2 binds GCAUG sequences in the terminal-loops of miRNA precursors and influences their processing to mature miRNAs.
Dr. Muhammad Afzal Dogar studied biotechnology at the National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad and Quaid-i-Azam University (QAU) Islamabad. He joined Friedrich Miescher Institute (FMI) Basel for training and later obtained his PhD in Biology and Medicine from Swiss Federal Institute of Technology, Lausanne. He worked as postdoctoral Senior Scientist at the Swiss Federal Institute of Technology (ETH), Zurich. He Currently employed as a Scientific Assistant (Wiss. Assistant) at Inselspital Bern, Switzerland.