Biology Talk on Post Translational Modifications of Tumour Suppressor Protein FBW7

Tuesday, February 6, 2018 - 12:45pm
Smart Room, 4th Floor, SBASSE Building, LUMS

Department of Biology presents

Posttranslational Modifications of Tumour Suppressor Protein FBW7 – Crises Comes with Opportunity

Guest Speaker: Dr. Omar Khan

Date: February 6, 2018
Time: 12:45 pm – 1:45 pm
Venue: Smart Room, 4thFloor, SBASSE Building, LUMS

Host:  Dr. Aziz Mithani

Abstract
FBW7 is a potent tumour suppressor with genetic mutations in many different cancers. The goal of my research is to understand the mechanisms regulating the FBW7 activity. We have employed two different approaches to address this issue. 1) FBW7 immunoprecipitation followed by Mass spectrometric analysis of FBW7 interacting proteins and 2) Pooled shRNA library screen to screen for modulators of FBW7 stability in an FBW7-GFP reporter cell line. 

About the Speaker
Dr. Omar Khan Completed his MSc in Biochemistry in 2003 from the University of Karachi. Later he moved to Sweden and did an MSc in Cell Biology in 2006 from the Uppsala University. Dr. Khan got his PhD in Molecular Medicine from Gothenburg University, Sweden in 2012. From 2013 onwards, he has been working as a postdoctoral scientist at the Francis Crick Institute, London at Dr. Axel Behren’s Lab.